An organoid is a three-dimensional construct composed of multiple cell types that originates from stem cells through self-organization and can simulate the architecture and functionality of native organs. As cutting-edge in vitro models, organoids have great potential in stem cells and development, regenerative medicine, disease research, drug development, and precision medicine.
Organoid Applications and Services
Organoid Modeling and Identification
Organoids and Precision Medicine
Cellular Organoid Engineering
Organoids, as preclinical models of human diseases, can not only be used for sensitivity test of chemotherapeutic drugs, targeted drugs, new anti-tumor antibodies, etc., but also for sensitivity test of in vitro radiotherapy. Therefore, organoids can assist with clinical treatment decisions, and effectively optimize the allocation of medical resources and save medical insurance resources. For patients, drug sensitivity testing utilizing organoids can quickly target the most suitable drug therapies for patients at various stages of the disease, reducing the toxicity and side effects of drugs, the risk of drug resistance and the probability of tumor recurrence, and easing the financial burden on patients.
Organoidare used to evaluate the tumor-killing effect and normal tissue toxicity of anti-tumor drugs; combined with the mutant phenotype and drug screening of organoids, the correlation between known mutants and specific drugs can be verified, and multiple chemical drugs that havekilling effects on tumors can be identified. More importantly, in addition to drug screening, the organoid bank can also be used for comparative genomic and proteomic analyses of tumor and normal tissue organoids from different patients, so as to achieve accurate assessment of the tumor status of patients, and provide supportive information for personalized treatment of tumors. The co-culture of tumor organoids with immune cells can realize rapid and effective detection of the killing effect of immune cells on tumor cells.
Stem cell research has become an important branch of biological research. With the development of life sciences, human beings want to better understand life and overcome various diseases, and are not only satisfied with experimenting on animal models. Therefore, scientists are eager to make progress in replicating and reconstructing human organs. In this context, organoids were born. Simply put, organoids are miniature three-dimensional organs grown from somatic cells, adult stem cells or pluripotent stem cells in vitro. There are highly undifferentiated totipotent cells that can transform into all human tissues and organs.
Organoid Applications and Services
Organoid Modeling and Identification
Organoids, as preclinical models of human diseases, can not only be used for sensitivity test of chemotherapeutic drugs, targeted drugs, new anti-tumor antibodies, etc., but also for sensitivity test of in vitro radiotherapy. Therefore, organoids can assist with clinical treatment decisions, and effectively optimize the allocation of medical resources and save medical insurance resources. For patients, drug sensitivity testing utilizing organoids can quickly target the most suitable drug therapies for patients at various stages of the disease, reducing the toxicity and side effects of drugs, the risk of drug resistance and the probability of tumor recurrence, and easing the financial burden on patients.
Organoids and Precision Medicine
Organoidare used to evaluate the tumor-killing effect and normal tissue toxicity of anti-tumor drugs; combined with the mutant phenotype and drug screening of organoids, the correlation between known mutants and specific drugs can be verified, and multiple chemical drugs that havekilling effects on tumors can be identified. More importantly, in addition to drug screening, the organoid bank can also be used for comparative genomic and proteomic analyses of tumor and normal tissue organoids from different patients, so as to achieve accurate assessment of the tumor status of patients, and provide supportive information for personalized treatment of tumors. The co-culture of tumor organoids with immune cells can realize rapid and effective detection of the killing effect of immune cells on tumor cells.
Cellular Organoid Engineering
Stem cell research has become an important branch of biological research. With the development of life sciences, human beings want to better understand life and overcome various diseases, and are not only satisfied with experimenting on animal models. Therefore, scientists are eager to make progress in replicating and reconstructing human organs. In this context, organoids were born. Simply put, organoids are miniature three-dimensional organs grown from somatic cells, adult stem cells or pluripotent stem cells in vitro. There are highly undifferentiated totipotent cells that can transform into all human tissues and organs.
